“Inflationary T cell memory” is a specific form of immunological memory that arises during the chronic phase of cytomegalovirus (CMV) infection. In preclinical animal models, CMV, genetically engineered to express defined vaccine antigens, has shown immense promise for induction of protective inflationary T cell memory, directed against HIV or Tuberculosis. In this project we track the development of memory inflation starting out from individual cytotoxic T cells. Based on this unique single-cell-based perspective, we will identify the precursors of long-lived memory T cells. We will then explore ways of selectively inducing their early development and thereby provide new strategies for enhancing the efficiency of vaccination and immunotherapy.


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Here you can find the press release of the current publication in Nature Immunology.