Project description:
PD Dr Dieter Henrik Heiland, at Freiburg University Hospital, focuses on glioblastomas the most malignant tumors of the central nervous system. Despite various therapeutic approaches, no cure has been found for glioblastoma. One hypothesis for the low therapeutic success represents the tumor environment, which is a barrier for anti-tumor immunity. In Cancer Cell, Heiland et al, publish a topographical characterization of gene expression, metabolism, and genetic alterations in glioblastomas and show that tumor cells adapt to inflammatory stimuli and/or metabolites in the environment. The tumor milieu is largely responsible for the changes in the tumor and should be the focus of future therapies.
Publication:
Ravi VM, Will P, Kueckelhaus J, Sun N, Joseph K, Salié H, Vollmer L, Kuliesiute U, von Ehr J, Benotmane JK, Neidert N, Follo M, Scherer F, Goeldner JM, Behringer SP, Franco P, Khiat M, Zhang J, Hofmann UG, Fung C, Ricklefs FL, Lamszus K, Boerries M, Ku M, Beck J, Sankowski R, Schwabenland M, Prinz M, Schüller U, Killmer S, Bengsch B, Walch AK, Delev D, Schnell O, Heiland DH.
Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma.
Cancer Cell. 2022 Jun 13;40(6):639-655.e13.
Paper: https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00220-3
Submitting the Paper of the Month:
Else Kröner-Fresenius-Stiftung is using the series “Paper of the Month” to report in an exemplary and hot-off-the-press style on the outstanding work being done by the scientists it supports. We regularly present publications which have recently appeared in especially renowned journals, have emerged from foundation funding and been given appropriate acknowledgment. This is done in the respective categories “Original Paper” and “Review”. In the case of each of these publications, the first author and/or senior author are being funded by the foundation.
We invite all project managers, fellowship recipients and members of graduate study programs to send their work in accordance with the stated criteria as proposal for Paper of the Month to Ms. Anne Asschenfeldt (a.asschenfeldt@ekfs.de).
