Project description:
A team of researchers from the Universities of Aarhus and Hamburg, as well as international partner institutes, led by Prof. Victor Puelles, has developed a new method for imaging and analyzing proteins in pathology samples. The results were published in the journal Nature. The method, called “Pathology-oriented multiPlexing” or PathoPlex for short, enables the visualization of over 100 proteins in a single tissue sample, thus providing detailed traceability of the expression and interaction of different proteins. A resolution approximately 1,000 times smaller than a human hair can be achieved. With the help of the specialized software “spatiomic” (https://spatiomic.org), also developed as part of PathoPlex, which can automatically recognize protein expression patterns, differences between various diseases, such as kidney disease in the context of diabetes, can be detected. This can contribute to the development of improved diagnostic tools and new therapies.
Publication:
Malte Kuehl, Yusuke Okabayashi, Milagros N. Wong, Lukas Gernhold, Gabriele Gut, Nico Kaiser, Maria Schwerk, Stefanie K. Gräfe, Frank Y. Ma, Jovan Tanevski, Philipp S. L. Schäfer, Sam Mezher, Jacobo Sarabia del Castillo, Thiago Goldbeck-Strieder, Olga Zolotareva, Michael Hartung, Fernando M. Delgado Chaves, Lukas Klinkert, Ann-Christin Gnirck, Marc Spehr, David Fleck, Mehdi Joodaki, Victor Parra, Mina Shaigan, … Victor G. Puelles
Submitting the Paper of the Month:
Else Kröner-Fresenius-Stiftung is using the series “Paper of the Month” to report in an exemplary and hot-off-the-press style on the outstanding work being done by the scientists it supports. We regularly present publications which have recently appeared in especially renowned journals, have emerged from foundation funding and been given appropriate acknowledgment. This is done in the respective categories “Original Paper” and “Review”. In the case of each of these publications, the first author and/or senior author are being funded by the foundation.
We invite all project managers, fellowship recipients and members of graduate study programs to send their work in accordance with the stated criteria as proposal for Paper of the Month to Ms. Anne Asschenfeldt (a.asschenfeldt@ekfs.de).
More Paper of the Month can be found here.
