Project description:
Excessive inflammation of the intestinal mucosa is a hallmark of inflammatory bowel disease. While current therapeutic options aim to restrain pro-inflammatory immune cells, the adoptive transfer of expanded anti-inflammatory (regulatory) lymphocytes is a promising approach for the future. Researchers from Erlangen have now developed a method to modify these regulatory lymphocytes in vitro to express a specific receptor on their surface that is important for recruitment to the gut. This did not reduce the anti-inflammatory properties of the cells and might substantially improve the effectiveness of the therapeutic approach in the future.
Publication:
Müller TM, Liu LJ, Wiesinger M; TRR241 IBDome Consortium; Neurath MF, Voskens CJ, Zundler S. Engineering Therapeutic Regulatory T Cells to Overexpress GProtein-Coupled Receptor 15 Improves Functional Fitness for In Vivo Gut Homing. Gastroenterology. 2025 Feb
Paper: https://www.sciencedirect.com/science/article/pii/S0016508524055653
Submitting the Paper of the Month:
Else Kröner-Fresenius-Stiftung is using the series “Paper of the Month” to report in an exemplary and hot-off-the-press style on the outstanding work being done by the scientists it supports. We regularly present publications which have recently appeared in especially renowned journals, have emerged from foundation funding and been given appropriate acknowledgment. This is done in the respective categories “Original Paper” and “Review”. In the case of each of these publications, the first author and/or senior author are being funded by the foundation.
We invite all project managers, fellowship recipients and members of graduate study programs to send their work in accordance with the stated criteria as proposal for Paper of the Month to Ms. Anne Asschenfeldt (a.asschenfeldt@ekfs.de).
More Paper of the Month can be found here.
