June 2024: $$ Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes

Journal: Nature Medicine 2024
Author: Dr. Kami Pekayvaz
Institution: Medizinische Klinik I, LMU Klinikum

Project description: 

Myocardial infarction and chronic coronary syndromes are key causes of morbidity and mortality worldwide. In a current and pioneering study, scientists from LMU Klinikum and Helmholtz Munich could build an atlas of immune signatures in acute and chronic coronary syndromes and could identify signatures that associate with the disease course. Using a novel analysis method (Multi-Omic Factor Analysis – MOFA) they could identify complex patterns within the Multi-Omics data and ultimately summarize small but coordinated immune-signatures into compact overarching Factors. This atlas on immune-signatures in myocardial infarction could form a relevant basis for further translational cardiovascular research.


Kami Pekayvaz, Corinna Losert, Viktoria Knottenberg, Christoph Gold, Irene V. van Blokland, Roy Oelen, Hilde E. Groot, Jan Walter Benjamins, Sophia Brambs, Rainer Kaiser, Adrian Gottschlich, Gordon Victor Hoffmann, Luke Eivers, Alejandro Martinez-Navarro, Nils Bruns, Susanne Stiller, Sezer Akgöl, Keyang Yue, Vivien Polewka, Raphael Escaig, Markus Joppich, Aleksandar Janjic, Oliver Popp, Sebastian Kobold, …Konstantin Stark, Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes. Nature Medicine (2024). Published: 21 May 2024

Paper: https://www.nature.com/articles/s41591-024-02953-4

Submitting the Paper of the Month:

Else Kröner-Fresenius-Stiftung is using the series “Paper of the Month” to report in an exemplary and hot-off-the-press style on the outstanding work being done by the scientists it supports. We regularly present publications which have recently appeared in especially renowned journals, have emerged from foundation funding and been given appropriate acknowledgment. This is done in the respective categories “Original Paper” and “Review”. In the case of each of these publications, the first author and/or senior author are being funded by the foundation.

We invite all project managers, fellowship recipients and members of graduate study programs to send their work in accordance with the stated criteria as proposal for Paper of the Month to Ms. Anne Asschenfeldt (a.asschenfeldt@ekfs.de).

More Paper of the Month can be found here.

Anne Asschenfeldt
Anne Asschenfeldt
Scientific Funding: Ongoing Project Funding and Fellowships